Compass

What is Compass?

THE COMPREHENSIVE SOLUTION FOR DETERMINING ADAPTIVE DOSES

High failure levels in Phase 3 trials generally reflect inaccurate dose selection during Phase 2. The complexities of designing and implementing initial phased dose determination studies can lead to time-consuming, resource-consuming losses. Traditional Phase 2 development programs often use a sequence of two clinical trials (one trial for proof of concept, followed by another for dose determination). A single adaptive dose determination study can replace these two traditional studies to obtain better information on dose selection and reduce study time and size.

The advantages of the compass

Compass provides the main comprehensive package for the design and implementation of adaptive clinical trials for dose determination.

It equips decision makers with a series of statistical tools to compare and select the best study designs. Execution and monitoring tools enable users to make informed and reliable interim decisions in real time, with full documentation and audit trail.

Design: Compass features a selection of test design options (Bayesian and Frequentist) not found in any other software package. Informationsimulations are fast, accurate, and cost-effective, allowing users to easily and frequently compare and contrast design options.

Execution: Compass uses adaptive tools that quickly conduct intermediate analyses necessary for dose adaptation based on empirical data. All dose interactions, calculations, and designations are captured and stored for complete documentation.

Benefits

Empowerment

Play a more strategic role in your organization: Compass simplifies and automates the design and simulation of adaptive studies for dose determination, allowing users to redirect critical time, attention, and resources to other vital aspects of clinical trial success.

Shares

Convince your team of the merits of your project: powerful simulations and customizable tables, charts and tables, facilitate clear communication with colleagues and authorities. Promote a collaborative environment for project teams by sharing projects in real time.

Evaluate

Optimize your r test projects: Quickly manage multiple adaptive or conventional early-phase projects, perform sensitivity analyses to assess their robustness to critical assumptions, and use sophisticated tables and charts to compare and document the operational characteristics of different approaches.

Reliable

Compass has undergone intensive testing and validation in industry and academia.

Resources

Simulations

Perform extensive simulations using an intuitive interface without the need for programming. Simulation outputs are stored in a versatile database structure for easy access during additional analysis.

Interim Monitoring Panel

Easily group data from various branches of a clinical study for efficient monitoring throughout the study. Useful summary tables and graphs allow for simplified interaction with interim data.

Transfer of information

Enjoy direct data transfers that quickly export random data and import response data.

Flexible decision-making rules

Benefit from complex tools that assist in making decisions about early stops, adaptive dose abandonment, and test extensions. Additional functions can be added through the R code.

Assessment integrity

Access a log file that details all calculations and intermediate monitoring decisions to confirm the integrity of an assessment.

System requirements:

CPU: 1.8 GHz dual core processor

RAM: 2 GB

HDD / SSD: 50 GB of free space on the main drive

Operating system: Microsoft Windows 8 32-bit, Microsoft Windows 7 32-bit and Microsoft Windows Vista 32-bit

Resolution: 1024×768